Key result
Beta-blockers can be used relatively safely in pulmonary arterial hypertension patients with comorbidities such as arrhythmias or hypertension without detrimental effects on survival.
Why the study?
Does beta-blocker therapy affect survival or time-to-clinical worsening in patients with pulmonary arterial hypertension?
Does beta-blocker therapy affect survival or time-to-clinical worsening in patients with pulmonary arterial hypertension?
Answers are grounded in this paper and cite their sources.
Emerging observational evidence suggests beta-blockers can be used safely in PAH patients with comorbidities like arrhythmias or hypertension, challenging current guideline recommendations against their use, though RCTs are still needed before advocating them for right heart failure.
Current guidelines advise against the use of β-blockers in pulmonary arterial hypertension (PAH) to avoid systemic hypotension [1]. In addition, PAH patients have a fixed stroke volume, and are therefore highly dependent on heart rate to increase their cardiac output [2–4]. Indeed, Provencher et al . [5] showed that withdrawal of β-blockers significantly improved exercise capacity in portopulmonary hypertension. Peacock and Ross [6] described another case of portopulmonary hypertension, in which the use of a β-blocker to treat a supraventricular tachycardia in an already haemodynamically unstable patient was nearly fatal. Beta-blockers can be used safely by some PAH patients with comorbidities such as arrhythmias or hypertension <http://ow.ly/P2JHg>
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Man et al. (2015) conducted an editorial in Pulmonary arterial hypertension (PAH). Beta-blockers vs. No beta-blocker use was evaluated on Survival and time-to-clinical worsening. Beta-blockers can be used relatively safely in pulmonary arterial hypertension patients with comorbidities such as arrhythmias or hypertension without detrimental effects on survival.
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