A norbornene-mediated palladium-catalyzed tandem alkylation/C−H functionalization sequence is described, in which an alkyl−aryl bond and a heteroaryl−aryl bond are formed in one pot. A variety of highly substituted six- and seven-membered ring annulated indoles were synthesized in good yields from bromoalkyl indoles and aryl iodides.
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Bressy et al. (2005) studied this question.
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