Key result
Lower serum RBP4 levels are linked to Kawasaki disease and coronary artery lesions.
Why the study?
RBP4 influences vasodilation and inhibits platelet activation, prompting investigation into its relationship with inflammation and thrombogenesis in children with Kawasaki disease.
Are serum retinol-binding protein 4 (RBP4) levels associated with coronary artery lesions and markers of inflammation and thrombogenesis in children with Kawasaki disease?
Cross-Sectional (n=79)
No
Are serum retinol-binding protein 4 (RBP4) levels associated with coronary artery lesions and markers of inflammation and thrombogenesis in children with Kawasaki disease?
Serum RBP4 is significantly decreased in children with acute Kawasaki disease—particularly those with coronary artery lesions—and correlates inversely with inflammatory and pro-thrombotic markers, suggesting a potential protective role in KD vasculitis.
Lower RBP4 associates with Kawasaki disease and coronary lesions; hypothesis-generating for protective role, needs prospective validation.
Background . Kawasaki disease (KD) is a self‐limited vasculitis with unknown etiologies, and coronary artery lesions (CALs) are the most common and serious complications. Retinol‐binding protein 4 (RBP4) has been confirmed effects on vasodilation, platelet activation inhibition, and cardiovascular diseases by researches. Therefore, this study was aimed at investigating the relationship between RBP4 and inflammation as well as thrombogenesis in children with KD. Methods . 79 subjects were from 62 children with KD and 17 healthy controls (HCs). The KD group was divided into KD with CALs (KD‐CALs) and KD without CALs (KD‐NCALs), and the serum RBP4 levels were measured by enzyme‐linked immunosorbent assay (ELISA). Results . Compared with the HC group, serum RBP4 levels in the KD group were significantly decreased ( p < 0.05). RBP4, hemoglobin (Hb), and mean platelet volume (MPV) levels were higher, while platelet counts (Plt) and thrombin time (TT) levels were lower in the KD‐NCALs group than in the KD‐CALs group ( p < 0.05). RBP4 had positive correlation with time point of intravenous immunoglobulin (IVIG), Hb, and percentage of leukomonocytes (L%) and negative correlation with the percentage of neutrophils (N%), MPV, C‐reactive protein (CRP), neutrophil‐to‐lymphocyte ratio (NLR), prothrombin time (PT), fibrinogen (Fbg), and D‐dimer (DD) in the KD group; RBP4 had positive correlation with the time point of IVIG and L% and negative correlation with N%, MPV, and NLR in the KD‐NCALs group; and RBP4 had positive correlation with Hb and L% and negative correlation with N%, CRP, NLR, and PT in the KD‐CALs group ( p < 0.05). Multiple linear regression analysis confirmed that Hb and CRP in the KD group, MPV and N% in the KD‐NCALs group, and PT and CRP in the KD‐CALs group were independent predictors of RBP4 ( p < 0.05). Conclusion . Lower RBP4 was observed in the KD group than in the HC group, and RBP4 had associations with markers of inflammation and thrombogenesis in children with KD.
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Yang et al. (2021) conducted a cross-sectional in Kawasaki disease (n=79). Serum retinol-binding protein 4 (RBP4) levels in Kawasaki disease vs. Healthy controls and Kawasaki disease without coronary artery lesions (KD-NCALs) was evaluated on Serum retinol-binding protein 4 (RBP4) levels and association with coronary artery lesions (CALs), inflammation, and thrombogenesis (p=<0.05). Serum RBP4 levels were significantly lower in children with Kawasaki disease than in healthy controls (p < 0.05) and lower in those with coronary artery lesions than without (p < 0.05).
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