Key result
Children with previous Kawasaki disease had significantly increased CD41-platelet expression at rest (14.3 vs 12.4 mfi, P=0.01) and after ADP stimulation compared with matched controls.
Case-Control (n=28)
Absolute Event Rate: 14.3% vs 12.4%
p-value: p=.01
Children with a history of Kawasaki disease exhibit increased platelet activation despite normal vascular function, suggesting a potential mechanism for long-term cardiovascular risk.
May indicate persistent platelet activation after Kawasaki disease; hypothesis-generating for long-term thrombotic risk without practice change.
We investigated whether children with a previous Kawasaki disease (KD) have evidence of abnormal vascular and/or platelet function. We included 14 patients with previous KD and 14 matched controls. We assessed endothelial function by flow-mediated dilation (FMD), carotid intima-media thickness (cIMT), coronary microvascular function by coronary blood flow response (CBFR) to cold pressor test, and platelet reactivity by measuring monocyte-platelet aggregates (MPAs) and CD41-platelet expression by flow cytometry. No differences were found between the groups in FMD, cIMT, or CBFR to cold pressor test. The MPAs were similar in patients with KD and controls. CD41-platelet expression, however, was significantly increased in patients with KD compared with controls, both at rest (14.3 ± 1.9 vs 12.4 ± 1.9 mean fluorescence intensity [mfi], P = .01) and after adenosine diphosphate stimulation (19.3 ± 1.3 vs 17 ± 1.7 mfi, P < .001). In conclusion, children with a previous episode of KD showed increased platelet activation, compared with healthy participants despite no apparent vascular abnormality at follow-up.
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Laurito et al. (2013) conducted a case-control in Kawasaki disease (n=28). Previous Kawasaki disease vs. Matched controls was evaluated on CD41-platelet expression at rest (p=.01). Children with previous Kawasaki disease had significantly increased CD41-platelet expression at rest (14.3 vs 12.4 mfi, P=0.01) and after ADP stimulation compared with matched controls.
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