Population
Actin filaments (in vitro model)
Comparison
mDia1-FH2 (formin) vs Absence of formin
Design
Preclinical
Authors
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Formin-induced actin flexibility changes may affect cardiac myofilament proteins; leaves open relevance to contractility or disease.
Formins regulate actin filament flexibility through long-range allosteric interactions, which may modulate the affinity of actin-binding proteins.
Bugyi et al. (2006) studied this question.
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