Key result
Early use of ≥2 immunotherapeutic agents predicted favorable outcomes in necrotizing autoimmune myopathy, whereas prednisone monotherapy was insufficient to control disease in 30 of 32 patients (90%).
Observational (n=63)
No
Necrotizing autoimmune myopathy is frequently associated with statin use, cancer, or connective tissue disease, and typically requires early aggressive immunosuppressant therapy with 2 or more agents rather than corticosteroid monotherapy.
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May support early multi-agent immunotherapy; extends observational data but leaves open need for randomized confirmation.
Kassardjian et al. (2015) conducted an observational in Necrotizing Autoimmune Myopathy (n=63). Immunosuppressant therapy vs. Prednisone monotherapy was evaluated on Predictors of response to treatment. Early use of ≥2 immunotherapeutic agents predicted favorable outcomes in necrotizing autoimmune myopathy, whereas prednisone monotherapy was insufficient to control disease in 30 of 32 patients (90%).
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