Key result
Activated brown adipose tissue was associated with a significantly higher intensity of myocardial [18F] FDG uptake compared to controls without activated brown fat (mean score 2.50 vs 2.13, p=0.031).
Why the study?
The study was designed to investigate the relationship between brown adipose tissue activation and the intensity and patterns of myocardial [18F] FDG uptake.
Does brown adipose tissue activation affect the intensity and pattern of myocardial [18F] FDG uptake?
Case-Control (n=102)
No
Does brown adipose tissue activation affect the intensity and pattern of myocardial [18F] FDG uptake?
The presence of activated brown adipose tissue is associated with higher intensity of myocardial [18F] FDG uptake, which is important to recognize to avoid misinterpretation of cardiac PET/CT findings.
The aim of this study is to investigate the relationship between brown adipose tissue (BAT) activation and myocardial fluorine-18-fluorodeoxyglucose ([18F] FDG) uptake in terms of intensity and patterns. The patients were divided into two groups as follows: BAT and control groups. The BAT group consists of 34 cases that showed BAT uptake. The control group, with no BAT uptake, included 68 patients who were matched for body mass index, gender, and season. The scans were retrospectively reviewed by two nuclear medicine physicians who visually evaluated the intensity of myocardial [18F] FDG uptake. The myocardial [18F] FDG uptake was visually classified into the following three patterns: diffuse, heterogeneous, and focal. The regions of activated BAT distribution were noted. The mean myocardial [18F] FDG uptake was 2.50 ± 0.75 for the BAT group and 2.13 ± 0.88 for the control group with a statistically significant difference (P = 0.031). The myocardial [18F] FDG uptake pattern was similar in the BAT and control groups with the diffuse pattern being the most common, followed by the heterogeneous and less commonly focal. In the BAT group, the anatomical distribution of BAT was mainly in supraclavicular, paravertebral, and axillary and to a lesser extent in cervical regions. BAT group had a significantly higher intensity of [18F] FDG myocardial uptake compared to that of the control group. The presence of activated BAT did not affect the pattern of myocardial uptake. Knowledge of these findings may help in understanding the variability of myocardial [18F] FDG uptake and consequently in avoiding misinterpretation of cardiac findings in positron-emission tomography/computed tomography studies.
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Alenezi et al. (2020) conducted a case-control in Oncological indications (n=102). Brown adipose tissue (BAT) activation vs. No BAT activation was evaluated on Mean intensity of myocardial [18F] FDG uptake (p=0.031). Activated brown adipose tissue was associated with a significantly higher intensity of myocardial [18F] FDG uptake compared to controls without activated brown fat (mean score 2.50 vs 2.13, p=0.031).
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