Key result
Digital resilience biomarkers, which dynamically evaluate biological responses to external challenges using wearable sensors, offer a promising strategy for personalized health maintenance.
Why the study?
It was unknown whether digital self-measurements can sensitively detect subtle disbalances in disease progression or the effects of preventive interventions.
Digital resilience biomarkers, combining continuous wearable measurements with dynamic biological responses, hold potential for personalized health maintenance and early disease prevention.
Answers are grounded in this paper and cite their sources.
Should not yet change clinical monitoring; hypothesis-generating for digital resilience metrics in cardiovascular prevention.
Health maintenance and disease prevention strategies become increasingly prioritized with increasing health and economic burden of chronic, lifestyle-related diseases. A key element in these strategies is the empowerment of individuals to control their health. Self-measurement plays an essential role in achieving such empowerment. Digital measurements have the advantage of being measured non-invasively, passively, continuously, and in a real-world context. An important question is whether such measurement can sensitively measure subtle disbalances in the progression toward disease, as well as the subtle effects of, for example, nutritional improvement. The concept of resilience biomarkers, defined as the dynamic evaluation of the biological response to an external challenge, has been identified as a viable strategy to measure these subtle effects. In this review, we explore the potential of integrating this concept with digital physiological measurements to come to digital resilience biomarkers. Additionally, we discuss the potential of wearable, non-invasive, and continuous measurement of molecular biomarkers. These types of innovative measurements may, in the future, also serve as a digital resilience biomarker to provide even more insight into the personal biological dynamics of an individual. Altogether, digital resilience biomarkers are envisioned to allow for the measurement of subtle effects of health maintenance and disease prevention strategies in a real-world context and thereby give personalized feedback to improve health.
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Brink et al. (2021) conducted a review in Health maintenance and disease prevention. Digital resilience biomarkers was evaluated. Digital resilience biomarkers, which dynamically evaluate biological responses to external challenges using wearable sensors, offer a promising strategy for personalized health maintenance.
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