Key result
Gestational diabetes and normal pregnancy both showed increased nocturnal plasma noradrenaline compared to non-pregnant controls (P=0.003 and P=0.002), with no difference between the pregnant groups.
Why the study?
Is autonomic nervous system imbalance present at night in women with gestational diabetes compared to healthy pregnant and non-pregnant controls?
Population
77 women, including 41 with gestational diabetes, 22 healthy pregnant controls, and 14 non-pregnant controls.
Design
Cross-sectional
Authors
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Indicates pregnancy-related nocturnal noradrenaline rise independent of gestational diabetes; leaves open autonomic links to future cardiometabolic risk.
Observational (n=77)
Is autonomic nervous system imbalance present at night in women with gestational diabetes compared to healthy pregnant and non-pregnant controls?
p-value: p=0.003
Gestational diabetes is associated with an inhibitory effect on autonomic nervous system modulation at the heart level, evidenced by a lack of normal nocturnal heart rate variability fluctuation.
Pöyhönen‐Alho et al. (2010) conducted an observational in Gestational diabetes (n=77). Gestational diabetes vs. Healthy pregnant controls and non-pregnant controls was evaluated on Plasma noradrenaline levels at 04.00 and 07.00 h (p=0.003). Gestational diabetes and normal pregnancy both showed increased nocturnal plasma noradrenaline compared to non-pregnant controls (P=0.003 and P=0.002), with no difference between the pregnant groups.
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