Key result
Clozapine responders (37.5% of patients) showed significantly higher approximate and sample entropy values of heart rate variability at 8 weeks compared to nonresponders.
Why the study?
Do nonlinear complexity measures of heart rate variability indicate therapeutic response to clozapine in patients with treatment-resistant schizophrenia?
Population
40 patients with treatment-resistant schizophrenia
Design
Cohort
Follow-up
8 weeks
Authors
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Does not support using HRV entropy to guide clozapine therapy; leaves open its role as a biomarker in resistant schizophrenia.
Observational (n=40)
Do nonlinear complexity measures of heart rate variability indicate therapeutic response to clozapine in patients with treatment-resistant schizophrenia?
Nonlinear complexity measures of HRV (ApEn and SampEn) may serve as useful electrophysiological markers to indicate therapeutic response to clozapine in treatment-resistant schizophrenia.
Kim et al. (2012) conducted an observational in Treatment-resistant schizophrenia (n=40). Clozapine response vs. Clozapine nonresponse was evaluated on Approximate entropy (ApEn) and sample entropy (SampEn) values of heart rate variability at week 8. Clozapine responders (37.5% of patients) showed significantly higher approximate and sample entropy values of heart rate variability at 8 weeks compared to nonresponders.
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