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February 1, 2001Journal of Clinical Psychopharmacology

Effects of Newer Atypical Antipsychotics on Autonomic Neurocardiac Function: A Comparison Between Amisulpride, Olanzapine, Sertindole, and Clozapine

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Why the study?

Do atypical antipsychotics (amisulpride, olanzapine, sertindole, clozapine) alter autonomic neurocardiac function in patients with schizophrenia?

Population

51 medication-free inpatients with schizophrenia (DSM-III-R-diagnosed) and 70 well-matched healthy controls.

Comparison

Atypical antipsychotics for an average of 14.1… vs Pre-treatment baseline and 70 well-matched…

Design

Cohort

Follow-up

average 14.1 days

Authors

MAM.W. AgelinkTMT MajewskiCWC. Wurthmann

Discussion

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Overview

Sertindole-associated QTc prolongation may warrant monitoring in schizophrenia; leaves open arrhythmic risk and need for prospective trials.

Structured PICO

Do atypical antipsychotics (amisulpride, olanzapine, sertindole, clozapine) alter autonomic neurocardiac function in patients with schizophrenia?

P
Population
51 medication-free inpatients with schizophrenia (DSM-III-R-diagnosed) and 70 well-matched healthy controls.
I
Intervention
Atypical antipsychotics for an average of 14.1 days: amisulpride 400 mg/day (n=12), olanzapine 20 mg/day (n=13), sertindole 12 mg/day (n=13), or clozapine 100 mg/day (n=13).
C
Comparator
Pre-treatment baseline (before-after comparison) and 70 well-matched healthy controls.
O
Outcome
Autonomic neurocardiac function measured by conventional electrocardiograms (QTc, resting heart rate) and 5-minute resting heart rate variability (HRV).surrogate

Atypical antipsychotics, particularly sertindole and clozapine, significantly alter autonomic neurocardiac function by prolonging QTc, increasing resting heart rate, and reducing parasympathetic tone.

Cite This Study

Agelink et al. (2001) studied this question.

synapsesocial.com/papers/6a708ddab5c1fe5ca9dfba77https://doi.org/10.1097/00004714-200102000-00003
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Also Consider

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