Why the study?
Does acute administration of antipsychotic drugs (risperidone, olanzapine, thioridazine) alter heart rate variability compared to placebo in healthy male volunteers?
Does acute administration of antipsychotic drugs (risperidone, olanzapine, thioridazine) alter heart rate variability compared to placebo in healthy male volunteers?
Different antipsychotics have distinct acute effects on heart rate variability, suggesting HRV could serve as a reliable surrogate index for assessing their cardiotoxic potential.
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Acute antipsychotic effects on HRV may guide selection in cardiac-risk patients; extends HRV validation as cardiotoxicity surrogate.
Silke et al. (2002) studied this question.