Why the study?
Does treatment with haloperidol, olanzapine, or risperidone alter cardiovascular variability in patients with recent-onset schizophrenia?
Population
108 subjects including patients with recent-onset schizophrenia and healthy controls.
Comparison
Treatment with haloperidol, olanzapine, or… vs Unmedicated patients with schizophrenia and…
Design
Cohort
Authors
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Haloperidol may reduce autonomic variability more than olanzapine; hypothesis-generating and should not yet change prescribing in recent-onset schizophrenia.
Does treatment with haloperidol, olanzapine, or risperidone alter cardiovascular variability in patients with recent-onset schizophrenia?
In young patients with recent-onset schizophrenia, haloperidol, risperidone, and olanzapine induced only minor cardiovascular side effects related to autonomic functioning.
Hempel et al. (2008) studied this question.
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