Key result
Haloperidol treatment did not significantly alter high frequency heart rate variability (PNN50) compared to a drug-free condition in schizophrenia patients (8.4 vs 8.3; P=0.5).
Why the study?
Does haloperidol treatment reduce heart rate variability in patients with schizophrenia?
RCT (n=7)
Double-blind
Does haloperidol treatment reduce heart rate variability in patients with schizophrenia?
Absolute Event Rate: 8.4% vs 8.3%
p-value: p=.5
Typical neuroleptic treatment with haloperidol does not appear to cause the low heart rate variability observed in patients with schizophrenia.
No takes yet. Share an insight, caveat, or question.
Haloperidol does not reduce HRV in schizophrenia; confirms low HRV as intrinsic to the disorder rather than drug-induced.
Malaspina et al. (2002) conducted an RCT in Schizophrenia (n=7). Haloperidol vs. Placebo / Drug-free condition was evaluated on High frequency heart rate variability (PNN50) (p=.5). Haloperidol treatment did not significantly alter high frequency heart rate variability (PNN50) compared to a drug-free condition in schizophrenia patients (8.4 vs 8.3; P=0.5).
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