Why the study?
Does schizophrenia and the use of atypical antipsychotics impair heart rate variability compared to healthy controls?
Population
43 subjects including 19 patients with schizophrenia and 24 healthy controls matched for age and gender.
Comparison
Atypical antipsychotics vs Medication-free schizophrenia patients and…
Design
Case-control
Follow-up
24 hours
Authors
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Schizophrenia-associated vagal impairment may elevate arrhythmic risk; Level 4 data leaves open whether HRV monitoring should guide therapy.
Does schizophrenia and the use of atypical antipsychotics impair heart rate variability compared to healthy controls?
Schizophrenia is associated with decreased cardiac vagal function independent of medication, and atypical antipsychotics further exacerbate this impairment in heart rate variability.
Mujica‐Parodi et al. (2004) studied this question.
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