Key result
Schizophrenia linked to markedly lower vagal activity on high-frequency HRV vs healthy controls.
Why the study?
Does schizophrenia diagnosis associate with reduced resting vagal activity (HRV) compared to healthy controls?
Meta-Analysis
Does schizophrenia diagnosis associate with reduced resting vagal activity (HRV) compared to healthy controls?
Effect estimate: Hedges' g -0.98 (95% CI -1.56 to -0.41)
p-value: p=0.0008
Individuals with schizophrenia exhibit significantly lower resting vagal activity (measured by HRV) compared to healthy controls, suggesting it may serve as an endophenotype for psychotic symptoms.
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Warrants autonomic assessment in schizophrenia care; confirms lower vagal activity as a robust endophenotype.
Clamor et al. (2016) conducted a meta-analysis in Schizophrenia. Schizophrenia vs. Healthy controls was evaluated on Vagal activity indicated by high-frequency HRV (Hedges' g -0.98, 95% CI -1.56 to -0.41, p=0.0008). Schizophrenia was associated with significantly lower vagal activity, indicated by high-frequency HRV, compared to healthy controls (Hedges' g -0.98; 95% CI -1.56 to -0.41; P=0.0008).
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