Why the study?
Do clozapine and olanzapine differentially affect pulse rate variability in patients with schizophrenia compared to healthy controls?
Population
20 patients with schizophrenia (DSM-III-R criteria) and 10 healthy controls (total n=30).
Comparison
Clozapine or olanzapine. vs Healthy controls.
Design
Cross-sectional
Authors
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Clozapine-associated PRV reduction may indicate greater autonomic effects than olanzapine; cross-sectional data leave causal cardiovascular implications open in schizophrenia.
Do clozapine and olanzapine differentially affect pulse rate variability in patients with schizophrenia compared to healthy controls?
Clozapine causes a significantly greater reduction in pulse rate variability and alters sympatho-vagal balance compared to olanzapine in patients with schizophrenia.
Müeck‐Weymann et al. (2002) studied this question.
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