Key result
The presence of ascending or abdominal aortic dilations was not associated with higher platelet aggregation or increased frequencies of hyperresponsiveness in men aged 65-74 years.
Why the study?
Platelets have been suggested as potential targets to slow aortic dilation expansion and rupture risk, but the association of increased in vitro platelet aggregation and hyperresponsiveness with ATAD and AAD required evaluation.
Cross-Sectional (n=566)
Yes
In vitro platelet aggregation is not altered in men with aortic aneurysms, suggesting that platelet inhibitors may not be effective targets for slowing aortic expansion.
Answers are grounded in this paper and cite their sources.
Platelet aggregation unaltered in men with ATADs/AADs; leaves open platelet targeting to slow dilation and warrants prospective trials.
Introduction Platelets play an important role in arterial diseases that extends beyond their traditional function in hemostasis and thrombosis.[ 1 ] The development and progression of ascending thoracic aortic dilations (ATADs) and abdominal aortic dilations (AADs) have been associated with increased platelet activation response.[ 1 ] [ 2 ] Consequently, platelets have been suggested as potential medical targets to slow expansion rates and reduce risk of ruptures. This study aimed to evaluate if increased in vitro platelet aggregation and hyperresponsiveness of platelets were associated with the presence of ATAD and AAD, and to estimate potential correlations between platelet activation response and ascending and abdominal aortic diameters, respectively. Note All authors listed above take responsibility for the reliability and freedom from bias of data presented and interpreted in this article. Publication History Received: 23 June 2023 Accepted: 08 September 2023 Accepted Manuscript online: 12 September 2023 Article published online: 23 October 2023 © 2023. Thieme. All rights reserved. Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany
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Obel et al. (2023) conducted a cross-sectional in Ascending thoracic and abdominal aortic dilations (n=566). Ascending thoracic and abdominal aortic dilations vs. Men without aortic dilations was evaluated on In-vitro platelet aggregation and hyperresponsiveness. The presence of ascending or abdominal aortic dilations was not associated with higher platelet aggregation or increased frequencies of hyperresponsiveness in men aged 65-74 years.
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