Key result
AAA linked to severe platelet dysfunction uncorrected by normal platelet transfusion.
Case Report (n=1)
This case report describes a novel finding of platelet dysfunction associated with an abdominal aortic aneurysm that was unresponsive to platelet transfusion.
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Platelet transfusion may not correct dysfunction in abdominal aortic aneurysm; leaves open novel acquired disorder requiring confirmation.
An 82-year-old man with a one-year history of spontaneous ecchymoses and posttraumatic bleeding was found on physical examination to have a pulsatile abdominal mass. Ultrasonography revealed a large abdominal aortic aneurysm with a freely moving 1.5--2-cm intraluminal thrombus. Laboratory data disclosed intravascular hemolysis, disseminated intravascular coagulation, and a prolonged bleeding time. Further investigation of platelet function demonstrated decreased glass bead retention (0-15%), and reduced or delayed aggregation responses to adenosine diphosphate, epinephrine, and collagen. Studies of platelet factor 3 availability, antiplatelet antibodies, and aggregation response to ristocetin were normal. Transfusion of ten units of normal platelets failed to shorten the patient's bleeding time, despite a marked rise in platelet count. Glass bead retention studies on normal and patient blood were not altered by mixture with patient and normal platelet-poor plasma, respectively. Platelet dysfunction in the presence of arterial aneurysm does not appear to have been reported previously.
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Fouser et al. (1980) conducted a case report in Abdominal Aortic Aneurysm (n=1). Abdominal aortic aneurysm was evaluated on Platelet function. An abdominal aortic aneurysm was associated with severe platelet dysfunction that was not corrected by transfusion of normal platelets.
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