Key result
The abstract describes the methodology for evaluating 2D and 3D speckle-tracking echocardiography to identify CAD in intermediate-risk patients, but does not report any results.
Why the study?
Does resting 2D and 3D speckle-tracking echocardiography accurately identify coronary artery disease in intermediate-risk patients with a positive exercise ECG test?
Observational
Does resting 2D and 3D speckle-tracking echocardiography accurately identify coronary artery disease in intermediate-risk patients with a positive exercise ECG test?
Background: Non-invasive assessment of stable coronary artery disease (CAD) remains challenging in the everyday practice. Despite widespread use of stress echocardiography, CMR and SPECT, according to the 2013 ESC guidelines on stable CAD management, exercise ECG testing (ECG-T) remains the most widely non-invasive used method. Speckle tracking imaging is a promising new method to evaluate ischemic heart disease. Aims: We investigated the diagnostic value of 2D and 3D speckle tracking echocardiography in intermediate risk patients with normal global and regional systolic function referred for angiocoronarography due to positive ECG-T. Methods: Consecutive suspected CAD patients with positive ECG-T were included. The ESC recommended clinical pretest probability (PPT) of CAD was evaluated in all patients. 2D speckle-tracking echocardiography was performed the day prior to planed coronary angiography and included Global longitudinal strain (GLS), Global post systolic shortening (GPSS), Global early systolic lengthening (GESL) and Territorial longitudinal strain (TLS). The following 3D speckle-tracking parameters were acquired: Global longitudinal strain (3DTGLS), Global radial strain (3DTGRS), Global circumferential strain (3DTGCS), Global area strain (3DTGAS) and Global and segmental Torsion and Twist rate. CAD was defined as the presence of at least one stenosis ≥50% in diameter. ROC analysis was performed to determine the cut-off value of 2D-Strain and 3D strain parameters that optimally identified the presence of CAD.
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Marchandot et al. (2017) conducted an observational in Suspected coronary artery disease (CAD). 2D and 3D speckle-tracking echocardiography vs. Coronary angiography (reference standard) was evaluated on Presence of CAD (defined as at least one stenosis ≥50% in diameter). The abstract describes the methodology for evaluating 2D and 3D speckle-tracking echocardiography to identify CAD in intermediate-risk patients, but does not report any results.
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