Key result
Esmolol pretreatment effectively attenuated the desflurane-induced heart rate increase compared to saline control (84.2 vs 108.8 beats/min at 1.5 MAC, p<0.001) and increased parasympathetic activity.
Why the study?
Does esmolol pretreatment attenuate heart rate increase and parasympathetic inhibition during rapid increases in desflurane concentration in healthy females undergoing minor breast surgery?
Population
16 American Society of Anesthesiologists physical status I female subjects, aged 20 to 50 years, undergoing…
Comparison
Esmolol 0.5 mg/kg i.v. administered before rapid… vs i.v. saline administered before rapid increases…
Design
RCT, randomly assigned to 2 groups
Follow-up
During anesthesia induction and desflurane inhalation
Authors
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Esmolol may blunt desflurane tachycardia; hypothesis-generating and should not yet change practice.
RCT (n=16)
Single-blind (data analyst)
Sealed envelope technique
No
Does esmolol pretreatment attenuate heart rate increase and parasympathetic inhibition during rapid increases in desflurane concentration in healthy females undergoing minor breast surgery?
Absolute Event Rate: 84.2% vs 108.8%
p-value: p=<0.001
Esmolol pretreatment (0.5 mg/kg i.v.) effectively mitigates the transient heart rate increase and parasympathetic inhibition caused by rapid escalation of desflurane concentration during anesthesia induction.
Kao et al. (2017) conducted an RCT in General anesthesia with desflurane for minor breast surgery (n=16). Esmolol vs. i.v. saline was evaluated on Mean heart rate at 1.5 MAC of desflurane (p=<0.001). Esmolol pretreatment effectively attenuated the desflurane-induced heart rate increase compared to saline control (84.2 vs 108.8 beats/min at 1.5 MAC, p<0.001) and increased parasympathetic activity.
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