Population
Cultured cell lines including NIH 3T3 fibroblasts and HeLa cells
Comparison
Overexpression of ACAP1 and ACAP2 vs ASAP1 or baseline cellular function
Design
Preclinical
Authors
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May inform Arf6 trafficking in cardiovascular cells; leaves open in vivo validation.
ACAP1 and ACAP2 are identified as Arf6 GAPs that regulate membrane trafficking and actin cytoskeleton in the cell periphery.
Jackson et al. (2000) studied this question.
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