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May 1, 1953Circulation ResearchOpen Access

The Distensibility Characteristics of the Portal Vascular Bed

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Population

Splanchnic portion of the portal system (specific model not stated in abstract)

Design

Preclinical

Authors

RARobert AlexanderBowling Green State UniversityWEW. Sterling EdwardsNational Center for Health StatisticsJAJay L. AnkeneyUniversity Hospitals of Cleveland

Discussion

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Implication

May explain splanchnic pooling during sustained venous hypertension; leaves open translation to human portal physiology.

Key Points

  • This research aims to evaluate the distensibility characteristics of the portal vascular bed.
  • Studied pressure and volume changes in the portal system.
  • Evaluated conditions with and without interruption of blood flow.
  • Identified two types of distensibility: rapid elastic distension and delayed compliance.
  • Delayed compliance is significant for blood pooling in peripheral vessels during elevated venous pressure.

Structured PICO

P
Population
Splanchnic portion of the portal system (specific model not stated in abstract)
I
Intervention
Evaluation of pressure and volume changes with or without interruption of blood flow
O
Outcome
Distensibility characteristics (pressure and volume changes)surrogate

Delayed compliance in the portal vascular bed plays a major role in the pooling of blood under conditions of maintained elevated venous pressure.

Cite This Study

Alexander et al. (1953) studied this question.

synapsesocial.com/papers/6a75b1cf72aedb66d66a3a1bhttps://doi.org/10.1161/01.res.1.3.271
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Responses of the relaxed and contracted portal vein to imposed stretch and shortening at graded rates1983 · 8 citations
  2. 2Dynamic changes in venous outflow by baroreflex and left ventricular distension1988 · 15 citations
  3. 3The Relationship between Active Constriction and Passive Recoil of the Veins at Various Distending Pressures1967 · 104 citations
  4. 4Effects of Distension on Mesenteric Blood Flow and O2 Saturation of Venous Blood in the Dog Intestinal Loop1979 · 2 citations
  5. 5‘Distensibility’ of the papaverine‐relaxed vascular bed in human subcutaneous tissue1979 · 8 citations