Answers are grounded in this paper and cite their sources.
SUMMARY Crude tetanus toxin paralyses the cholinergic innervation of the sphincter pupillae of the rabbit eye. To test whether this activity was due to tetano-spasmin or to a non-spasmogenic fraction with a peripheral effect, the action of crude tetanus toxin and of the non-spasmogenic fraction prepared from it were compared in rabbits. The paralytic action of the crude toxin was not due to its content of the non-spasmogenic fraction and was probably due to tetanospasmin itself. A convenient method for the preparation of a mixture of the four most abundant gangliosides is given. The preparation of a ganglioside cerebroside complex and its use for the removal of tetanospasmin from a solution of crude tetanus toxin are described.
No takes yet. Share an insight, caveat, or question.
Mellanby et al. (1968) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: