Key result
Older APOE E4 allele carriers exhibited significantly reduced complexity of resting BOLD signals in the precuneus and posterior cingulate regions compared to noncarriers.
Why the study?
Does the APOE ɛ4 allele affect the complexity and functional connectivity of resting brain activity in healthy adults?
Cross-Sectional (n=212)
No
Does the APOE ɛ4 allele affect the complexity and functional connectivity of resting brain activity in healthy adults?
Absolute Event Rate: 1.32% vs 1.42%
p-value: p=0.036
The APOE ɛ4 allele is associated with reduced complexity of resting brain activity and compensatory increased functional connectivity in older, but not younger, healthy adults.
Should not change practice in healthy adults; hypothesis-generating for APOE ε4 effects on brain aging and dementia risk.
The apolipoprotein E (APOE) gene is associated with structural and functional brain changes. We have used multiscale entropy (MSE) analysis to detect changes in the complexity of resting blood oxygen level-dependent (BOLD) signals associated with aging and cognitive function. In this study, we further hypothesized that the APOE genotype may affect the complexity of spontaneous BOLD activity in younger and older adults, and such altered complexity may be associated with certain changes in functional connectivity. We conducted a resting-state functional magnetic resonance imaging experiment in a cohort of 100 younger adults (aged 20-39 years; mean 27.2 ± 4.3 years; male/female: 53/47) and 112 older adults (aged 60-79 years; mean 68.4 ± 6.5 years; male/female: 54/58), and applied voxelwise MSE analysis to assess the main effect of APOE genotype on resting-state BOLD complexity and connectivity. Although the main effect of APOE genotype on BOLD complexity was not observed in younger group, we observed that older APOE ɛ4 allele carriers had significant reductions in BOLD complexity in precuneus and posterior cingulate regions, relative to noncarriers. We also observed that reduced BOLD complexity in precuneus and posterior cingulate regions was associated with increased functional connectivity to the superior and inferior frontal gyrus in the older group. These results support the compensatory recruitment hypothesis in older APOE ɛ4 carriers, and confer the impact of the APOE genotype on the temporal dynamics of brain activity in older adults.
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Yang et al. (2013) conducted a cross-sectional in Healthy adults (n=212). APOE E4 allele vs. APOE E4 noncarriers was evaluated on Multiscale entropy (MSE) of BOLD signals in the left posterior cingulate and left precuneus in older adults (p=0.036). Older APOE E4 allele carriers exhibited significantly reduced complexity of resting BOLD signals in the precuneus and posterior cingulate regions compared to noncarriers.
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