Key result
The APOEepsilon4 allele in young healthy adults was associated with greater neural activity in frontal areas and cingulate gyri during a visual working memory task.
Why the study?
Does the presence of the APOEε4 allele alter neural activity in young healthy adults?
Population
Young healthy adults with and without the APOEε4 allele
Comparison
Presence of the APOEε4 allele vs Absence of the APOEε4 allele (APOEε4-)
Design
Cross-sectional
Authors
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May indicate early neural changes in APOEε4 carriers; hypothesis-generating and leaves open predictive value for Alzheimer's risk.
Cross-Sectional
Does the presence of the APOEε4 allele alter neural activity in young healthy adults?
The APOEε4 allele is associated with physiological neural alterations in young healthy adults before aging, potentially contributing to early Alzheimer's disease risk.
Filbey et al. (2006) conducted a cross-sectional in Healthy. APOEepsilon4 allele vs. APOEepsilon4- (without the allele) was evaluated on Neural activity measured by functional magnetic resonance imaging and magnetoencephalography during a visual working memory task. The APOEepsilon4 allele in young healthy adults was associated with greater neural activity in frontal areas and cingulate gyri during a visual working memory task.
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