Key result
Adherence to dual antiplatelet therapy after drug-eluting stent placement was 94.2% at one month but declined to 46.8% at six months, with nonadherence associated with rural location, inactive occupation, and poor knowledge.
Why the study?
Adherence to dual antiplatelet therapy is critical after drug-eluting stent placement, but patient knowledge, adherence rates, trends over time, and factors associated with nonadherence in ACS patients needed assessment.
Observational (n=154)
Yes
DAPT adherence after DES placement in Vietnam drops significantly by 3 and 6 months, highlighting the need for targeted patient education, especially for rural and inactive patients with poor disease knowledge.
DAPT adherence drops sharply by six months after DES; leaves open targeted interventions for rural patients with poor knowledge but should not yet change practice.
Introduction: Adherence to dual antiplatelet therapy (DAPT) is critical after drug-eluting stent(DES) placement. We aimed to assess patient’s knowledge, rates of DAPT adherence, trends in DAPT use over time, and patient‐level factors associated with nonadherence in the patient with acute coronary syndrome (ACS). Methods: ACS patients who received one or more DES between May and September 2018from two hospitals in Vietnam and used DAPT after stent placement were eligible for a direct interview to assess patient’s knowledge on disease and DAPT. Telephone interviews were conducted one, three, and six months following discharge. Nonadherence was defined as premature discontinuation of DAPT. Factors related to nonadherent patients were analyzed using the chi-square test. Results: Of the 200 patients identified, 154 (77%) participated. Of the ten questions related to knowledge, the mean score of correct answers was 8.2 ± 2.3, and 71.7% had good knowledge.Adherence to DAPT was high at one month (94.2%) but declined by three months (44.2%) and then by six months (46.8%). Aspirin adherence was 99.3%-100% throughout. Three factors associated with nonadherence of DAPT following DES placement by six months included: rural location, linactive occupation, and inadequate knowledge on disease and DAPT (p<0.05). Conclusion: DAPT adherence is high at one month but is suboptimal at three and six months.Factors associated with the nonadherence of DAPT will be helpful in the planning of patient education strategies.
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Anh et al. (2021) conducted an observational in Acute coronary syndrome (n=154). Dual antiplatelet therapy (DAPT) was evaluated on Adherence to DAPT at 6 months. Adherence to dual antiplatelet therapy after drug-eluting stent placement was 94.2% at one month but declined to 46.8% at six months, with nonadherence associated with rural location, inactive occupation, and poor knowledge.
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