Key result
Elevated D-dimer levels are associated with an increased risk of stroke in patients with atrial fibrillation and may help guide anticoagulation decisions in low-risk patients.
Why the study?
Although D-dimer is associated with stroke development in patients with atrial fibrillation, it is not included in modern stroke risk stratification scales.
Does D-dimer level estimation improve stroke risk stratification in patients with atrial fibrillation?
Does D-dimer level estimation improve stroke risk stratification in patients with atrial fibrillation?
D-dimer testing may provide additional prognostic value for stroke risk in atrial fibrillation, particularly for guiding anticoagulation in patients with borderline CHA2DS2-VASc scores.
Should not yet guide anticoagulation in low-risk AF; leaves open prospective validation of D-dimer for risk stratification.
Introduction. D-dimer is an important indicator, which reflects the activation of intravascular blood coagulation and fibrinolytic system. There are some data confirming that D-dimer is associated with stroke development in patients with atrial fibrillation. However, D-dimer is not included in modern stoke risk stratification scales in patients with atrial fibrillation. Aim — to analyze the data devoted to the role of D-dimer in stroke risk stratification in patients with atrial fibrillation. General findings. D-dimer, despite several limitations, could be used in clinical practice as an indicator that is associated with stroke development in patients with atrial fibrillation. D-dimer level estimation could help to decide whether to use anticoagulant treatment in patients with low risk of stroke development or in those patients with a single non-sex CHA 2 DS 2 -VASc score risk factor.
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Рубаненко et al. (2022) conducted a review in Atrial fibrillation. D-dimer vs. Low or normal D-dimer levels was evaluated on Stroke development. Elevated D-dimer levels are associated with an increased risk of stroke in patients with atrial fibrillation and may help guide anticoagulation decisions in low-risk patients.
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