Key result
High-salt diet linked to ~70% rate of spontaneous ICH preceded by focal vascular permeability.
Observational (n=10)
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BACKGROUND AND PURPOSE: Stroke-prone spontaneous hypertensive rats (SHRsp) fed a high-salt diet develop malignant hypertension, blood-brain barrier breakdown, and spontaneous intracerebral hemorrhage (ICH). The precise spatial and temporal relationship between these events has not been well-delineated. METHODS: Ten SHRsp male rats, fed a high-salt diet, were imaged weekly using MRI, starting at 12 weeks of age. T1-weighted (with and without Gd), T2-weighted, and T2* sequences were acquired. Permeability maps were calculated. RESULTS: Seven SHRsp rats had spontaneous ICH develop before death. Five of the 7 rats had focally increased vascular permeability at the site of the ICH; 3 of these rats had vascular permeability 1 to 2 weeks before spontaneous ICH. CONCLUSIONS: Salt-loaded SHRsp rats have increased vascular permeability up to 2 weeks before ICH, predicting hemorrhage both in space and time. These results suggest that hypertensive ICH is preceded by focal vasculopathy detectable by Gd leak.
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Lee et al. (2007) conducted an observational in Spontaneous intracerebral hemorrhage and malignant hypertension (n=10). High-salt diet and weekly MRI with gadolinium permeability mapping was evaluated on Spontaneous intracerebral hemorrhage (ICH) preceded by focally increased vascular permeability. High-salt diet in SHRsp rats led to spontaneous ICH in 7 of 10 rats, with 5 of 7 showing focal vascular permeability at the bleed site (3 of 7 occurring 1-2 weeks prior).
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