Inhibition of the Insulin-like Growth Factor-1 Receptor (IGF1R) Tyrosine Kinase as a Novel Cancer Therapy Approach

ADVERTISEMENT RETURN TO ISSUEPerspectiveNEXTInhibition of the Insulin-like Growth Factor-1 Receptor (IGF1R) Tyrosine Kinase as a Novel Cancer Therapy ApproachRongshi Li*†, Alan Pourpak‡, and Stephan W. Morris*‡View Author Information† Drug Discovery, H. Lee Moffitt Cancer Center and Research Institute, Oncologic Sciences, University of South Florida, 12902 Magnolia Drive, Tampa, Florida 33612‡ Departments of Pathology and Oncology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105-3678*To whom correspondence should be addressed. For R.L.: phone, (813) 745-6485; fax, (813) 745-7264; e-mail, [email protected]. For S.W.M.: phone, (901) 595-3616; fax, (901) 595-2032; e-mail, [email protected]Cite this: J. Med. Chem. 2009, 52, 16, 4981–5004Publication Date (Web):July 17, 2009Publication History Received24 February 2009Published online17 July 2009Published inissue 27 August 2009https://pubs.acs.org/doi/10.1021/jm9002395https://doi.org/10.1021/jm9002395review-articleACS PublicationsCopyright © 2009 American Chemical SocietyRequest reuse permissionsArticle Views5332Altmetric-Citations105LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Cancer,Cell signaling,Cells,Inhibitors,Peptides and proteins Get e-Alerts