Key result
Renin inhibitors, specifically aliskiren, effectively decrease albuminuria in chronic kidney disease, but their impact on hard renal endpoints and cardiovascular events remains to be established.
Why the study?
Do direct renin inhibitors control hypertension, limit kidney disease progression, and decrease cardiovascular risk in patients with chronic kidney disease?
Do direct renin inhibitors control hypertension, limit kidney disease progression, and decrease cardiovascular risk in patients with chronic kidney disease?
While aliskiren decreases albuminuria in CKD, its impact on hard renal and cardiovascular endpoints is not yet established.
Aliskiren should not yet guide renal or CV protection in CKD; leaves open whether albuminuria reduction improves hard outcomes.
PURPOSE OF REVIEW: To evaluate the evidence supporting the use of renin inhibitors to control hypertension, limit kidney disease progression, and decrease cardiovascular risk in patients with chronic kidney disease (CKD). RECENT FINDINGS: The literature on the subject is still limited. Most of the studies have used aliskiren as the study drug. Animal models show improved survival and decreased renal injury in animals receiving aliskiren. Human studies in patients with normal renal function show effective blood pressure control alone or in combination with different agents. There are no studies focusing on blood pressure control in patients with CKD, though the drug has been safely used in CKD. In a randomized clinical trial, aliskiren decreased albuminuria when added to losartan in patients with early diabetic nephropathy. Ongoing studies are evaluating the role of renin inhibitors in the prevention of cardiovascular events and slowing of kidney disease progression in CKD. SUMMARY: Renin inhibitors, specifically aliskiren, effectively decrease albuminuria. Their role in improving hard renal endpoints and decreasing cardiovascular events in CKD still remains to be established.
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Peixoto et al. (2009) conducted a review in Chronic kidney disease. Direct renin inhibitors (aliskiren) was evaluated. Renin inhibitors, specifically aliskiren, effectively decrease albuminuria in chronic kidney disease, but their impact on hard renal endpoints and cardiovascular events remains to be established.
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