Key result
An overdose of 1400 mg of quetiapine in a 23-year-old female resulted in mild symptoms including drowsiness and supraventricular tachycardia, followed by an uneventful recovery with supportive care.
Case Report (n=1)
No
A 1400 mg quetiapine overdose resulted in supraventricular tachycardia and drowsiness but was managed safely with supportive care, supporting its relative safety in overdose scenarios.
Case of 1400 mg quetiapine overdose with mild effects suggests supportive care may suffice; leaves open safety at higher doses or in other patients.
Compared to other antipsychotics quetiapine has been reported to be relatively safer in overdose. We report a case with paranoid schizophrenia who attempted suicide with 1400 mg of quetiapine and manifested drowsiness, supraventricular tachycardia (167/minute) and minimal ST depression in leads V1 to V6 on ECG; all other physiological parameters were normal. Gastric lavage, lorazepam 2mg i/v to control agitation, and 14-hour observation in emergency ended in she being sent home. Subsequently she was successfully managed with ECTs, and quetiapine 600mg and risperidone 6mg daily. This report tends to support the literature suggesting quetiapine as a relatively-safer-in-overdose antipsychotic, and preferable in medication-overdose-suicidal-risk cases.
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Mattoo et al. (2009) conducted a case report in Quetiapine overdose in paranoid schizophrenia (n=1). Quetiapine overdose was evaluated on Clinical symptoms and recovery. An overdose of 1400 mg of quetiapine in a 23-year-old female resulted in mild symptoms including drowsiness and supraventricular tachycardia, followed by an uneventful recovery with supportive care.
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