October 1, 1997AJP Cell PhysiologyOpen Access

Cell cycle-dependent expression of a glioma-specific chloride current: proposed link to cytoskeletal changes

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Population

STTG1 cells (human anaplastic astrocytoma cell line)

Design

Preclinical

Authors

NUNicole J. UllrichBoston Children's Hospital HSHarald SontheimerUniversity of North Carolina at Chapel Hill

Discussion

Member takes

Implication

Remains preclinical for glioma; extends cell-cycle and cytoskeletal links but leaves open therapeutic relevance.

Structured PICO

Population

STTG1 cells (human anaplastic astrocytoma cell line)

Intervention

Cell cycle arrest (using serum starvation, mevastatin, hydroxyurea, demecolcine, and cytosine beta-D-arabinofuranoside) and disruption of F-actin (using cytochalasin D or osmotic cell swelling)

Outcome

Glioma Cl- channel (GCC) activitysurrogate

Glioma chloride channel activity is regulated during cell cycle progression and may be linked to cytoskeletal rearrangements.

Cite This Study

Ullrich et al. (1997) studied this question.

synapsesocial.com/papers/6a75b942b1c5cc4eb2b1cd79 https://doi.org/10.1152/ajpcell.1997.273.4.c1290

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Cell cycle-dependent expression of a glioma-specific chloride current: proposed link to cytoskeletal changes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cell cycle-dependent expression of a glioma-specific chloride current: proposed link to cytoskeletal changes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider