Key result
During a modified Head-up Tilt Test with provoked coughing, 44% of patients with a history of cough syncope experienced complete loss of consciousness, compared to 0% in the control group.
Why the study?
Does a modified head-up tilt test with provoked coughing reproduce symptoms and hemodynamic changes in patients with a history of cough syncope?
Case-Control (n=21)
No
Does a modified head-up tilt test with provoked coughing reproduce symptoms and hemodynamic changes in patients with a history of cough syncope?
Absolute Event Rate: 44% vs 0%
A modified head-up tilt test incorporating provoked coughing can reproduce syncope and demonstrate significant vasodepressor responses without bradycardia in patients with a history of cough syncope, supporting a complex cardiovascular mechanism rather than a purely cardioinhibitory one.
May support diagnostic evaluation in cough syncope; leaves open confirmation of mechanisms and clinical utility.
Coughing is a rare cause of syncope and the role of Tilt Table Test is not clear yet. The aim of this study was to describe the head-up tilt-test (TTT) and the occurrence of syncope with coughing during TTT in a small cohort of patients. A total of 5133 TTT were retrospectively analyzed to identify patients with cough syncope. A total of 9 patients (Male, age 51±14 years) with cough syncope were identified. Patients with cough syncope were compared to 12 age-matched control patients with syncope unrelated to coughing. Patients were made to cough on 3 separate occasions in an attempt to reproduce typical clinical symptoms on TTT. We present here the preliminary results of this ongoing study, as a confirm of dates described in literature.
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Vacacela et al. (2013) conducted a case-control in Cough syncope (n=21). Modified Head-up Tilt Test with provoked coughing vs. Control group (patients with syncope unrelated to coughing) was evaluated on Occurrence of syncope during provoked coughing on the Tilt Table Test. During a modified Head-up Tilt Test with provoked coughing, 44% of patients with a history of cough syncope experienced complete loss of consciousness, compared to 0% in the control group.
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