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Methodological analysis demonstrates efficient QTL detection for censored traits using the Cox model, suggesting improved genetic mapping for skewed data.
Most existing statistical methods for mapping quantitative trait loci (QTL) assume that the phenotype follows a normal distribution and that it is fully observed. However, some phenotypes have skewed distributions and may be censored. This note proposes a simple and efficient approach to QTL detecting for censored traits with the Cox PH model without estimating the baseline hazard function which is "nuisance".
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Yixin Fang (2006) studied this question.
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