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January 1, 2016ApmisOpen Access

The role of molecular mimicry and other factors in the association of Human Endogenous Retroviruses and autoimmunity

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Key result

Bioinformatic and molecular modelling techniques suggest the most convincing evidence for molecular mimicry is in rheumatoid arthritis, where HERV K-10 shares amino acid sequences with IgG1Fc.

Design

Review

Authors

MTMalgorzata TrelaUniversity of WolverhamptonPNPaul N. NelsonJames Cook UniversityPRP B RylanceThe Royal Wolverhampton NHS Trust

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Overview

Hypothesis-generating for HERV K-10 mimicry in RA; requires functional validation before clinical consideration.

PICO

P
Population
Autoimmune diseases
E
Exposure / Comparator
Human Endogenous Retroviruses (HERVs) and molecular mimicry

This review highlights the potential role of molecular mimicry between Human Endogenous Retroviruses and host proteins in the pathogenesis of autoimmune diseases like rheumatoid arthritis.

Cite This Study

Trela et al. (2016) conducted a review in Autoimmune diseases. Human Endogenous Retroviruses (HERVs) and molecular mimicry was evaluated. Bioinformatic and molecular modelling techniques suggest the most convincing evidence for molecular mimicry is in rheumatoid arthritis, where HERV K-10 shares amino acid sequences with IgG1Fc.

synapsesocial.com/papers/6a75bf2bb1c5cc4eb2b1ce16https://doi.org/10.1111/apm.12487
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