A dorsomedial prefrontal cortex-based dynamic functional connectivity model significantly predicted depressive rumination in an independent sample (r = 0.288) and depression scores in patients with major depressive disorder (r = 0.431).
Observational (n=288)
Yes
A whole-brain predictive model based on dynamic resting-state functional connectivity with the dorsomedial prefrontal cortex can generalize across datasets to predict trait rumination and depression scores.
Effect estimate: r = 0.288 (95% CI 0.004-0.589)
p-value: p=0.025
Rumination is a cognitive style characterized by repetitive thoughts about one's negative internal states and is a common symptom of depression. Previous studies have linked trait rumination to alterations in the default mode network, but predictive brain markers of rumination are lacking. Here, we adopt a predictive modeling approach to develop a neuroimaging marker of rumination based on the variance of dynamic resting-state functional connectivity and test it across 5 diverse subclinical and clinical samples (total n = 288). A whole-brain marker based on dynamic connectivity with the dorsomedial prefrontal cortex (dmPFC) emerges as generalizable across the subclinical datasets. A refined marker consisting of the most important features from a virtual lesion analysis further predicts depression scores of adults with major depressive disorder (n = 35). This study highlights the role of the dmPFC in trait rumination and provides a dynamic functional connectivity marker for rumination.
Kim et al. (Thu,) conducted a observational in Rumination and Major Depressive Disorder (n=288). Dorsomedial prefrontal cortex (dmPFC) dynamic functional connectivity was evaluated on Prediction of depressive rumination (RRS subscale) in an independent test dataset (r = 0.288, 95% CI 0.004-0.589, p=0.025). A dorsomedial prefrontal cortex-based dynamic functional connectivity model significantly predicted depressive rumination in an independent sample (r = 0.288) and depression scores in patients with major depressive disorder (r = 0.431).