Key result
Preoperative diuretic use was associated with a significantly increased incidence of major adverse events after cardiac surgery compared to no diuretic use (48% vs. 43%; P<0.0001).
Why the study?
Does preoperative diuretic use increase the risk of major adverse events in patients undergoing cardiac surgery?
Population
12,593 patients undergoing cardiac surgery at a single institution between January 1, 2000, and December 31…
Comparison
Preoperative diuretic use. vs No preoperative diuretic use.
Design
Cohort
Follow-up
in-hospital
Authors
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May warrant perioperative risk stratification; leaves open causality and need for prospective trials.
Cohort (n=12,593)
No
Does preoperative diuretic use increase the risk of major adverse events in patients undergoing cardiac surgery?
Absolute Event Rate: 48% vs 43%
p-value: p=< 0.0001
Preoperative diuretic use is associated with an increased incidence of major adverse events, including renal dysfunction and atrial fibrillation, after cardiac surgery.
Bandeali et al. (2013) conducted a cohort in Cardiac surgery (n=12,593). Preoperative diuretic use vs. No preoperative diuretic use was evaluated on Major adverse events (MAEs) defined as the composite of mortality, postoperative renal dysfunction, myocardial infarction, stroke, and new-onset atrial fibrillation (p=< 0.0001). Preoperative diuretic use was associated with a significantly increased incidence of major adverse events after cardiac surgery compared to no diuretic use (48% vs. 43%; P<0.0001).
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