Why the study?
Does low-dose furosemide infusion prevent postoperative renal dysfunction in high-risk cardiac surgical patients?
Population
n=42 high-risk cardiac surgical patients with preoperative serum creatinine >130 micromol/l…
Comparison
Furosemide infusion at 4 mg/h, commenced after… vs Saline infusion at 2 ml/h, commenced after…
Design
RCT, prospectively randomised, double-blinded placebo-controlled
Follow-up
Postoperative period
Authors
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Does not support prophylactic low-dose furosemide to prevent renal dysfunction after cardiac surgery; challenges assumptions of benefit in high-risk patients.
Does low-dose furosemide infusion prevent postoperative renal dysfunction in high-risk cardiac surgical patients?
Prophylactic low-dose furosemide infusion does not prevent renal dysfunction or reduce renal injury in high-risk patients undergoing cardiac surgery, despite increasing urine output.
Mahesh et al. (2008) studied this question.
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