Key result
Accelerated CKD progression occurred in 37.68% of patients at 24 months and was significantly associated with age (OR 1.04), higher baseline GFR, and higher diastolic blood pressure.
Why the study?
Characteristics and predictors of rapid CKD progression required further exploration, with no published studies on this topic in Colombia.
Cohort (n=14,420)
Odds Ratio: 1.04 (95% CI 1.02–1.06)
p-value: p=<0.0001
In a large Colombian cohort, approximately 30-40% of CKD patients were rapid progressors, with younger age, higher baseline GFR, and higher diastolic blood pressure associated with accelerated progression.
Identifies predictors of rapid CKD progression in Colombian cohort; hypothesis-generating and requires prospective validation before clinical use.
Background: Chronic Kidney Disease (CKD) is a global public health problem with increasing prevalence and a substantial burden on healthcare systems. The characteristics of rapid progressors and factors that may predict accelerated CKD progression require further exploration, especially since there are no published studies about this topic in Colombia. Purpose: To identify the clinical and sociodemographic factors associated with the rapid progression of CKD in a large cohort of Colombian patients. Methods: This retrospective observational study included two cohorts of G1 to G4 stage CKD patients without dialysis from the Colombian North Coast. Follow-up was conducted for 18 months (n=14,420) and 24 months (n=10,042). Patients were divided into rapid progressors and stable progressors based on the glomerular filtration rate (GFR) slope <?5 mL/min/1.73m2/year or ?-5 mL/min/1.73 m2/year, respectively. Results: 37.68% of the cohort was classified as rapid progressors at 24 months and 28.41% at 18 months. An R2=0.77 was found in both cohorts for GFR measurements, indicating a linear trend toward loss. Furthermore, accelerated progression was observed in younger patients and those with higher diastolic blood pressure values. Conclusion: In two large cohorts of renal patients, approximately 4 out of 10 patients were classified as rapid progressors at 24 months of follow-up and 3 out of 10 at 18 months of follow-up. It is important to identify patients at higher risk of accelerated CKD progression in the short term to provide them with personalized and effective care.
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Pereira‐Morales et al. (2023) conducted a cohort in Chronic Kidney Disease (n=14,420). Age was evaluated on Rapid progression of CKD at 24 months (GFR slope < -5 mL/min/1.73m2/year) (OR 1.04, 95% CI 1.02-1.06, p=<0.0001). Accelerated CKD progression occurred in 37.68% of patients at 24 months and was significantly associated with age (OR 1.04), higher baseline GFR, and higher diastolic blood pressure.
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