Key result
An overnight fast significantly reduced anxiety-like behavior and blocked acute stress-induced c-Fos activation in hindbrain GLP-1 and PrRP neurons in rats.
Why the study?
Does overnight fasting or central GLP-1 receptor antagonism reduce behavioral and neural responses to acute stress in rats?
Does overnight fasting or central GLP-1 receptor antagonism reduce behavioral and neural responses to acute stress in rats?
p-value: p=<0.001
A single overnight fast or central GLP-1 receptor antagonism attenuates behavioral and neuroendocrine responses to acute stress in rats.
No takes yet. Share an insight, caveat, or question.
Fasting attenuates anxiety-like behavior via hindbrain neurons in rats; leaves open translation to human stress disorders.
Maniscalco et al. (2015) studied Healthy (Acute Stress Model) (n=105). Overnight fasting (food deprivation) vs. Ad libitum feeding was evaluated on Anxiety-like behavior and neural c-Fos activation in GLP-1 and PrRP neurons (p=<0.001). An overnight fast significantly reduced anxiety-like behavior and blocked acute stress-induced c-Fos activation in hindbrain GLP-1 and PrRP neurons in rats.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: