In Vitro Antioxidant Activity and Hepatoprotective Potential Of Elaeis Guineensis Leaf Against Paracetamo lInduced Damage in Mice

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Elaeis guineensis, a medicinal herb, is commonly used in folk medicine to treat various diseases. The aim of the present study is to evaluate the in vitro antioxidant and in vivo hepatoprotective activity of E. guineensis against experimentally induced liver injury through serum analysis. Serum activity was measured by monitoring the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and billirubin. The extract exhibits in vitro antioxidant activity with an IC 50 value of 814 μg/mL in the DPPH radical scavenging activity and 37.48 μg/mL in xanthine oxidase inhibitory (XOI) activity. The results of the paracetamol- induced liver toxicity experiments indicated that mice treated with the E. guineensis leaf extract (200 mg/kg) showed a significant decrease in ALT, AST, and bilirubin levels, which were all elevated in the paracetamol treated group (p < 0.01). The hepatoprotective action is likely related to its potent in vitro antioxidant activity.