Key result
Ablation of PI3Kgamma in mice resulted in an approximately 35% greater spontaneous action potential frequency in sinoatrial node myocytes, driven by cAMP-dependent increases in L-type Ca2+ current.
Why the study?
Does genetic ablation of PI3Kgamma alter heart rate and sinoatrial node function in mice?
Does genetic ablation of PI3Kgamma alter heart rate and sinoatrial node function in mice?
Effect estimate: ~35% greater
PI3Kgamma regulates heart rate through cAMP-dependent modulation of sinoatrial node function, specifically by increasing L-type Ca2+ current.
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PI3Kgamma modulates murine sinoatrial automaticity; extends mechanistic insights but leaves open clinical translation.
Rose et al. (2007) studied this question. PI3Kgamma ablation vs. Wild-type (PI3Kgamma(+/+)) was evaluated on Spontaneous action potential frequency in isolated SAN myocytes (~35% greater). Ablation of PI3Kgamma in mice resulted in an approximately 35% greater spontaneous action potential frequency in sinoatrial node myocytes, driven by cAMP-dependent increases in L-type Ca2+ current.
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