Protein Carbamylation Predicts Mortality in ESRD
Key result
Elevated serum PBHCit in the highest tertile more than doubled the risk of death compared to the lowest tertile in patients with ESRD (adjusted HR 2.3; 95% CI 1.5-3.7).
Authors
Discussion
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Implication
PBHCit may aid mortality risk stratification in ESRD; observational data leave open its added value and require prospective confirmation.
Study Design
Type
Cohort (n=347)
PICO
P
Population
347 patients with ESRD undergoing maintenance hemodialysis, followed for 5 years.
E
Exposure / Comparator
Elevated serum protein-bound homocitrulline (PBHCit) vs Lowest tertile of PBHCit
O
Primary Outcome
Death — HR 2.3 (1.5-3.7), p=<0.01
Main Result
Hazard Ratio: 2.3 (95% CI 1.5–3.7)
p-value: p=<0.01
Cite This Study
Koeth et al. (2013) conducted a cohort in End-Stage Renal Disease (ESRD) (n=347). Elevated serum protein-bound homocitrulline (PBHCit) vs. Lowest tertile of PBHCit was evaluated on Death (HR 2.3, 95% CI 1.5-3.7, p=<0.01). Elevated serum PBHCit in the highest tertile more than doubled the risk of death compared to the lowest tertile in patients with ESRD (adjusted HR 2.3; 95% CI 1.5-3.7).