Impact of Type 2 Diabetes on Myocardial Insulin Sensitivity to Glucose Uptake and Perfusion in Patients with Coronary Artery Disease
Key result
Type 2 diabetes did not alter myocardial glucose uptake in nonstenotic (0.38 vs 0.36 micromol/g.min; P=NS) or stenotic regions in CAD patients with preserved LVEF.
Why the study?
Does type 2 diabetes induce myocardial insulin resistance, and does acute hyperinsulinemia alter myocardial perfusion in patients with coronary artery disease and preserved LVEF?
Population
27 patients with coronary artery disease and preserved LVEF, comprising 12 with type 2 diabetes mellitus and…
Comparison
Acute hyperinsulinemia vs Without acute hyperinsulinemia (rest)
Design
Cross-sectional
Authors
Discussion
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Implication
Myocardial glucose uptake appears preserved regardless of T2DM in CAD with preserved LVEF; leaves open whether resistance emerges in reduced LVEF or other phenotypes.
Study Design
Type
Cross-Sectional (n=27)
Structured PICO
Does type 2 diabetes induce myocardial insulin resistance, and does acute hyperinsulinemia alter myocardial perfusion in patients with coronary artery disease and preserved LVEF?
P
Population
27 patients with coronary artery disease and preserved LVEF (>50%), including 12 with type 2 diabetes and 15 without.
E
Exposure
Acute hyperinsulinemia
C
Comparator
Without acute hyperinsulinemia (rest)
O
Outcome
Regional myocardial and skeletal glucose uptake, and myocardial and skeletal muscle perfusion measured with positron emission tomography (PET)surrogate
Main Result
Absolute Event Rate: 0.38% vs 0.36%
p-value: p=NS
Myocardial insulin resistance to glucose uptake is not an inherent feature in T2DM patients with preserved LVEF, and acute insulin exposure does not cause coronary vasodilation in CAD patients regardless of T2DM status.
Cite This Study
Søndergaard et al. (2006) conducted a cross-sectional in Coronary artery disease (n=27). Type 2 diabetes mellitus vs. No type 2 diabetes was evaluated on Myocardial glucose uptake in nonstenotic regions (micromol/g.min) (p=NS). Type 2 diabetes did not alter myocardial glucose uptake in nonstenotic (0.38 vs 0.36 micromol/g.min; P=NS) or stenotic regions in CAD patients with preserved LVEF.