Myocardial insulin resistance in patients with syndrome X.
View Full Paper
Ask AI
Bookmark
Share
Why the study?
Do patients with syndrome X exhibit myocardial insulin resistance and altered cardiac energy metabolism compared to healthy controls?
Population
16 subjects: 8 patients with syndrome X and 8 healthy control subjects.
Comparison
Hyperinsulinemic-euglycemic clamp combined with… vs Healthy control subjects undergoing the…
Design
Case-control
Authors
Discussion
Loading...
Member takes
Implication
May indicate myocardial insulin resistance in syndrome X; hypothesis-generating for effects on cardiac energy metabolism.
Structured PICO
Do patients with syndrome X exhibit myocardial insulin resistance and altered cardiac energy metabolism compared to healthy controls?
P
Population
16 subjects: 8 patients with syndrome X (history of typical effort angina, positive exercise ECG, angiographically smooth coronary arteries without stenoses, mean age 54, 25% male) and 8 healthy control subjects (evaluated for atypical chest pain with normal exams and angiograms, mean age 51, 50% male).
I
Intervention
Hyperinsulinemic-euglycemic clamp (1.5-h constant 0.8 mU/kg/min infusion of insulin with euglycemia maintained by 20% glucose) combined with coronary sinus pacing at 150 beats per minute for 10 minutes.
C
Comparator
Healthy control subjects undergoing the identical hyperinsulinemic-euglycemic clamp and pacing protocol.
O
Outcome
Myocardial hemodynamics and metabolite exchanges (glucose, lipid, and carbohydrate oxidation) across the heart and forearm at rest, during pace stress, and in the recovery period.surrogate
Patients with syndrome X exhibit myocardial insulin resistance that is independent of myocardial blood flow, although their cardiac energy metabolism remains unaffected.
Cite This Study
Bøtker et al. (1997) studied this question.
View Full Paper
Ask AI
Bookmark
Share