Key result
The T1 mapping ratio of (pre M T1 - post M T1)/(pre L T1 - post L T1) was significantly higher in dilated cardiomyopathy patients compared to controls (0.50 vs 0.30, p<0.0001) and correlated with ejection fraction.
Why the study?
Which quantification method using myocardial T1 values is most reliable to estimate diffuse myocardial fibrosis in patients with dilated cardiomyopathy?
Cross-Sectional (n=62)
Single-blind
No
Which quantification method using myocardial T1 values is most reliable to estimate diffuse myocardial fibrosis in patients with dilated cardiomyopathy?
Absolute Event Rate: 0.5% vs 0.3%
p-value: p=<0.0001
The ratio of pre- and post-contrast myocardial T1 difference to left ventricular lumen T1 difference is a reliable cardiac MRI method to estimate disease severity in dilated cardiomyopathy.
May support T1 ratio for fibrosis estimation in DCM; leaves open prospective validation before clinical adoption.
Purpose: The purpose is to compare several quantification methods and clarify which quantification method is reliable to estimate diffuse myocardial fibrosis with cardiac MRI in patients with dilated cardiomyopathy (DCM) using myocardial T1 value. Methods and Results: Delayed enhancement imaging was performed in 52 patients with DCM and 10 control subjects to identify fibrosis using an inversion time scout sequence. The mean contrast-enhanced myocardial (M) T1 values of the pre and post contrast-enhanced myocardial and left ventricular lumen (L) of control and dilated cardiomyopathy cases were compared. The calculated post M T1 value, pre M T1 value-post M T1 value, and (pre M TI value-post M T1 value)/(pre L T1 value-post L T1 value) were significantly different between the patient group and the control group (344.5 ± 31.6 vs. 390.4 ± 19.3 msec, 239.9 ± 64.2 msec vs. 134.0 ± 28.9 msec, and 0.50 ± 0.11 vs. 0.30 ± 0.60, respectively). (Pre M T1 value-post M T1 value)/(pre L T1 value-post L T1 value) was significantly the most related to the left ventricular ejection fraction (r = 0.66, p < 0.0001). Conclusion: (Pre M T1 value-post M T1 value)/(pre L T1 value-post L T1 value) was the most reliable quantification method to estimate the severity of DCM.
No takes yet. Share an insight, caveat, or question.
Hayashida et al. (2013) conducted a cross-sectional in Dilated cardiomyopathy (n=62). Cardiac MRI T1 mapping ((pre M T1 - post M T1)/(pre L T1 - post L T1)) vs. Healthy controls was evaluated on (pre M T1 value-post M T1 value)/(pre L T1 value-post L T1 value) (p=<0.0001). The T1 mapping ratio of (pre M T1 - post M T1)/(pre L T1 - post L T1) was significantly higher in dilated cardiomyopathy patients compared to controls (0.50 vs 0.30, p<0.0001) and correlated with ejection fraction.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: