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June 5, 2018International Journal of Molecular SciencesOpen Access

The Role of High-Density Lipoproteins in Diabetes and Its Vascular Complications

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Key result

High-density lipoproteins (HDL) demonstrate potential to rescue diabetes-related vascular complications, although their protective functions can become dysfunctional in the diabetic milieu.

Population

Patients with diabetes mellitus (DM) and its vascular complications

Design

Review

Authors

NWNathan WongSNStephen J. NichollsJTJoanne T. M. Tan

Discussion

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Overview

HDL dysfunction in diabetes cautions against broad HDL-raising; leaves open whether restoring functionality improves vascular outcomes.

Structured PICO

P
Population
Patients with diabetes mellitus (DM) and its vascular complications
E
Exposure
High-density lipoproteins (HDL) and HDL-modifying therapies

This review highlights the complex role of HDL in diabetes, noting its potential protective effects against vascular complications and how these functions can become impaired in the diabetic milieu.

Cite This Study

Wong et al. (2018) conducted a review in Diabetes mellitus and vascular complications. High-density lipoproteins (HDL) was evaluated. High-density lipoproteins (HDL) demonstrate potential to rescue diabetes-related vascular complications, although their protective functions can become dysfunctional in the diabetic milieu.

synapsesocial.com/papers/6a75d23ef1e99ff85ab21871https://doi.org/10.3390/ijms19061680
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