Non-alcoholic fatty liver disease is significantly associated with a 1.5-fold higher risk of developing new-onset heart failure, independent of common cardiometabolic risk factors.
NAFLD is independently associated with an increased long-term risk of new-onset heart failure, highlighting the need for careful cardiovascular surveillance and a multidisciplinary management approach in these patients.
Hazard Ratio: 1.5 (95% CI 1.34–1.67)
valor p: p=<0.001
PURPOSE OF THE REVIEW: Non-alcoholic fatty liver disease (NAFLD) and heart failure (HF) are two chronic diseases that have become important global public health problems. This narrative review provides a comprehensive overview of the association between NAFLD and increased risk of new-onset HF, briefly discusses the putative biological mechanisms linking these two conditions, and summarizes targeted pharmacotherapies for NAFLD that might also beneficially affect cardiac complications leading to new-onset HF. RECENT FINDINGS: Recent observational cohort studies supported a significant association between NAFLD and the long-term risk of new-onset HF. Notably, this risk remained statistically significant even after adjustment for age, sex, ethnicity, adiposity measures, pre-existing type 2 diabetes and other common cardiometabolic risk factors. In addition, the risk of incident HF was further increased with more advanced liver disease, especially with higher severity of liver fibrosis. There are multiple potential pathophysiological mechanisms by which NAFLD (especially in its more advanced forms) may increase the risk of new-onset HF. Because of the strong link existing between NAFLD and HF, more careful surveillance of these patients will be needed. However, further prospective and mechanistic studies are required to better decipher the existing but complex link between NAFLD and risk of new-onset HF.
Inciardi et al. (Tue,) conducted a review in Non-alcoholic fatty liver disease (NAFLD) and Heart Failure. Non-alcoholic fatty liver disease vs. Absence of NAFLD was evaluated on New-onset heart failure (HR 1.50, 95% CI 1.34-1.67, p=<0.001). Non-alcoholic fatty liver disease is significantly associated with a 1.5-fold higher risk of developing new-onset heart failure, independent of common cardiometabolic risk factors.