Why the study?
Does trandolapril improve exercise capacity and energy utilization in rats with chronic heart failure?
Population
Rats with chronic heart failure (CHF) following coronary artery ligation (n=7 per group for specific assays)
Comparison
Trandolapril 1 mg kg day from the 2nd to 8th… vs Sham-operated rats and untreated rats with CHF
Design
Preclinical
Follow-up
6 weeks of treatment (from 2nd to 8th week after surgery)
Authors
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Hypothesis-generating in rat CHF model; leaves open any human translation or practice change.
Does trandolapril improve exercise capacity and energy utilization in rats with chronic heart failure?
Trandolapril improves exercise capacity and normalizes skeletal muscle energy utilization and contractile protein alterations in a rat model of chronic heart failure.
Yamaguchi et al. (1999) studied this question.
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